Claudin18.2 (CLDN18.2) CHO-K1 Cell Line
Description
Claudin18.2 (CLDN18.2) CHO-K1 Cell Line
Claudins are a family of proteins that maintain tight cell junctions. Claudins have different subtypes expressed on different tissues. Claudin 18 isoform 2 (CLDN18.2) expression in normal tissues is restricted to cells of the gastric mucosa. And CLDN18.2 is absent from other healthy tissues.
However, 70% of primary gastric adenocarcinomas and its metastases show CLDN18.2 expression. A number of other cancers, including pancreatic (50%), esophagus (30%) and NSCLC (25%) also show the CLDN18.2 expression. The restricted expression makes Cldn18.2 a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, evidenced by efforts in targeting CLDN18.2 via naked antibody and CAR-T modalities.
Claudin18.2 (CLDN18.2) CHO-K1 Cell Line is a useful tool for Claudins biology and related drug discovery.
Internal Reference:
SA-CAS9-162
Website URL:
/shop/sa-cas9-162-claudin18-2-cldn18-2-cho-k1-cell-line-33857
Discover similar products for quality control and assay validation in molecular diagnostics
explore the full range today!
Your Dynamic Snippet will be displayed here... This message is displayed because you did not provide both a filter and a template to use.